| 2025-05-25 | Southampton 1 - 2 Arsenal | Premier League |
| 2024-10-05 | Arsenal 3 - 1 Southampton | Premier League |
| 2023-04-21 | Arsenal 3 - 3 Southampton | Premier League |
| 2022-10-23 | Southampton 1 - 1 Arsenal | Premier League |
| 2022-04-16 | Southampton 1 - 0 Arsenal | Premier League |
| 2021-12-11 | Arsenal 3 - 0 Southampton | Premier League |
| 2021-01-26 | Southampton 1 - 3 Arsenal | League |
| 2021-01-23 | Southampton 1 - 0 Arsenal | FA Cup |
| 2020-12-16 | Arsenal 1 - 1 Southampton | League |
| 2020-06-25 | Southampton 0 - 2 Arsenal | League |
| 2019-11-23 | Arsenal 2 - 2 Southampton | League |
| 2019-02-24 | Arsenal 2 - 0 Southampton | League |
| 2018-12-16 | Southampton 3 - 2 Arsenal | League |
| 2018-04-09 | Arsenal 3 - 2 Southampton | League |
| 2017-12-10 | Southampton 1 - 1 Arsenal | League |
| 2017-05-10 | Southampton 0 - 2 Arsenal | League |
| 2017-01-28 | Southampton 0 - 5 Arsenal | FA Cup |
| 2016-11-30 | Arsenal 0 - 2 Southampton | EFL Cup |
| 2016-09-10 | Arsenal 2 - 1 Southampton | League |
| 2016-02-02 | Arsenal 0 - 0 Southampton | League |
| 2015-12-26 | Southampton 4 - 0 Arsenal | League |
| 2015-01-01 | Southampton 2 - 0 Arsenal | League |
| 2014-12-03 | Arsenal 1 - 0 Southampton | League |
| 2014-09-23 | Arsenal 1 - 2 Southampton | Capital One Cup |
| 2014-01-28 | Southampton 2 - 2 Arsenal | League |
| 2013-11-23 | Arsenal 2 - 0 Southampton | League |
| 2013-01-01 | Southampton 1 - 1 Arsenal | League |
| 2012-09-15 | Arsenal 6 - 1 Southampton | League |
| 2005-02-26 | Southampton 1 - 1 Arsenal | League |
| 2004-10-30 | Arsenal 2 - 2 Southampton | League |
| 2004-02-10 | Arsenal 2 - 0 Southampton | League |
| 2003-12-29 | Southampton 0 - 1 Arsenal | League |
| 2003-05-17 | Arsenal 1 - 0 Southampton | FA Cup |
| 2003-05-07 | Arsenal 6 - 1 Southampton | League |
| 2002-11-23 | Southampton 3 - 2 Arsenal | League |
| 2002-02-02 | Arsenal 1 - 1 Southampton | League |
| 2001-10-13 | Southampton 0 - 2 Arsenal | League |
| 2001-05-19 | Southampton 3 - 2 Arsenal | League |
| 2000-12-02 | Arsenal 1 - 0 Southampton | League |
| 2000-02-26 | Arsenal 3 - 1 Southampton | League |
| 1999-09-18 | Southampton 0 - 1 Arsenal | League |
| 1999-04-03 | Southampton 0 - 0 Arsenal | League |
| 1998-10-17 | Arsenal 1 - 1 Southampton | League |
| 1998-01-31 | Arsenal 3 - 0 Southampton | League |
| 1997-08-23 | Southampton 1 - 3 Arsenal | League |
| 1997-03-15 | Southampton 0 - 2 Arsenal | League |
| 1996-12-04 | Arsenal 3 - 1 Southampton | League |
| 1995-12-09 | Southampton 0 - 0 Arsenal | League |
| 1995-09-23 | Arsenal 4 - 2 Southampton | League |
| 1995-01-24 | Arsenal 1 - 1 Southampton | League |
| 1994-11-19 | Southampton 1 - 0 Arsenal | League |
| 1994-03-19 | Southampton 0 - 4 Arsenal | League |
| 1993-09-25 | Arsenal 1 - 0 Southampton | League |
| 1993-03-20 | Arsenal 4 - 3 Southampton | League |
| 1992-12-05 | Southampton 2 - 0 Arsenal | League |
| 1992-05-02 | Arsenal 5 - 1 Southampton | League |
| 1991-09-28 | Southampton 0 - 4 Arsenal | League |
| 1991-04-09 | Southampton 1 - 1 Arsenal | League |
| 1990-11-17 | Arsenal 4 - 0 Southampton | League |
| 1990-05-02 | Arsenal 2 - 1 Southampton | League |
| 1989-12-26 | Southampton 1 - 0 Arsenal | League |
| 1989-03-25 | Southampton 1 - 3 Arsenal | League |
| 1988-09-17 | Arsenal 2 - 2 Southampton | League |
| 1988-04-09 | Southampton 4 - 2 Arsenal | League |
| 1987-11-21 | Arsenal 0 - 1 Southampton | League |
| 1986-12-27 | Arsenal 1 - 0 Southampton | League |
| 1986-11-15 | Southampton 0 - 4 Arsenal | League |
| 1985-12-07 | Southampton 3 - 0 Arsenal | League |
| 1985-11-26 | Southampton 1 - 3 Arsenal | League Cup |
| 1985-11-19 | Arsenal 0 - 0 Southampton | League Cup |
| 1985-08-20 | Arsenal 3 - 2 Southampton | League |
| 1985-05-06 | Arsenal 1 - 0 Southampton | League |
| 1984-12-08 | Southampton 1 - 0 Arsenal | League |
| 1983-12-31 | Arsenal 2 - 2 Southampton | League |
| 1983-09-03 | Southampton 1 - 0 Arsenal | League |
| 1983-04-02 | Arsenal 0 - 0 Southampton | League |
| 1982-12-28 | Southampton 2 - 2 Arsenal | League |
| 1982-05-15 | Arsenal 4 - 1 Southampton | League |
| 1982-01-23 | Southampton 3 - 1 Arsenal | League |
| 1980-11-11 | Southampton 3 - 1 Arsenal | League |
| 1980-08-19 | Arsenal 1 - 1 Southampton | League |
| 1980-04-05 | Arsenal 1 - 1 Southampton | League |
| 1980-01-30 | Arsenal 2 - 1 Southampton | League Cup |
| 1980-01-01 | Southampton 0 - 1 Arsenal | League |
| 1979-03-21 | Arsenal 2 - 0 Southampton | FA Cup |
| 1979-03-19 | Southampton 1 - 1 Arsenal | FA Cup |
| 1979-03-03 | Southampton 2 - 0 Arsenal | League |
| 1978-10-21 | Arsenal 1 - 0 Southampton | League |
| 1978-01-30 | Arsenal 2 - 0 Southampton | League Cup |
| 1974-03-02 | Arsenal 1 - 0 Southampton | League |
| 1973-12-26 | Southampton 1 - 1 Arsenal | League |
| 1973-04-23 | Southampton 2 - 2 Arsenal | League |
| 1972-09-30 | Arsenal 1 - 0 Southampton | League |
| 1972-03-28 | Arsenal 1 - 0 Southampton | League |
| 1971-10-02 | Southampton 0 - 1 Arsenal | League |
| 1971-04-10 | Southampton 1 - 2 Arsenal | League |
| 1970-12-26 | Arsenal 0 - 0 Southampton | League |
| 1970-03-21 | Southampton 0 - 2 Arsenal | League |
| 1969-12-06 | Arsenal 2 - 2 Southampton | League |
| 1969-09-04 | Arsenal 2 - 0 Southampton | League Cup |
| 1969-09-02 | Southampton 1 - 1 Arsenal | League Cup |
| 1969-03-29 | Arsenal 0 - 0 Southampton | League |
| 1968-09-07 | Southampton 1 - 2 Arsenal | League |
| 1968-04-15 | Arsenal 0 - 3 Southampton | League |
| 1968-04-10 | Southampton 2 - 0 Arsenal | League |
| 1966-12-27 | Southampton 2 - 1 Arsenal | League |
| 1966-12-26 | Arsenal 4 - 1 Southampton | League |
| 1927-03-26 | Arsenal 2 - 1 Southampton | FA Cup |